[HTML][HTML] Mechanisms of coronavirus cell entry mediated by the viral spike protein
S Belouzard, JK Millet, BN Licitra, GR Whittaker - Viruses, 2012 - mdpi.com
Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm.
To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with …
To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with …
Host cell proteases: critical determinants of coronavirus tropism and pathogenesis
JK Millet, GR Whittaker - Virus research, 2015 - Elsevier
… of FIPV-1146 S, as the R to G mutation found at that site (Table 2) is reminiscent of the R to
… We are grateful to all members of the Whittaker laboratory for helpful discussions. This work …
… We are grateful to all members of the Whittaker laboratory for helpful discussions. This work …
Coronavirus membrane fusion mechanism offers a potential target for antiviral development
The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to
develop effective therapies against the causative agent, SARS-CoV-2, and also against other …
develop effective therapies against the causative agent, SARS-CoV-2, and also against other …
Network dea
This chapter describes network DEA models, where a network consists of sub-technologies.
A DEA model typically describes a technology to a level of abstraction necessary for the …
A DEA model typically describes a technology to a level of abstraction necessary for the …
Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites
…, VC Chu, GR Whittaker - Proceedings of the …, 2009 - National Acad Sciences
The coronavirus spike protein (S) plays a key role in the early steps of viral infection, with the
S1 domain responsible for receptor binding and the S2 domain mediating membrane fusion…
S1 domain responsible for receptor binding and the S2 domain mediating membrane fusion…
[PDF][PDF] β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway
β-Coronaviruses are a family of positive-strand enveloped RNA viruses that includes the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much is known regarding …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much is known regarding …
Phylogenetic analysis and structural modeling of SARS-CoV-2 spike protein reveals an evolutionary distinct and proteolytically sensitive activation loop
The 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) originally arose as part of a major
outbreak of respiratory disease centered on Hubei province, China. It is now a global …
outbreak of respiratory disease centered on Hubei province, China. It is now a global …
Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein
JK Millet, GR Whittaker - Proceedings of the National …, 2014 - National Acad Sciences
Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified betacoronavirus
causing high morbidity and mortality in humans. The coronavirus spike (S) protein is …
causing high morbidity and mortality in humans. The coronavirus spike (S) protein is …
Dissecting virus entry via endocytosis
SB Sieczkarski, GR Whittaker - Journal of General …, 2002 - microbiologyresearch.org
… In these cells, influenza virus entry was arrested at the level of the late endosome (SB
Sieczkarski, HA Brown and GR Whittaker, unpublished data), without any apparent defect in …
Sieczkarski, HA Brown and GR Whittaker, unpublished data), without any apparent defect in …
Influenza virus can enter and infect cells in the absence of clathrin-mediated endocytosis
SB Sieczkarski, GR Whittaker - Journal of virology, 2002 - Am Soc Microbiol
Influenza virus has been described to enter host cells via clathrin-mediated endocytosis.
However, it has also been suggested that other endocytic routes may provide additional entry …
However, it has also been suggested that other endocytic routes may provide additional entry …