… Ashrafi & G. Ruvkun, personal communication). Bacterial food and low temperature may
normally upregulate serotonin signaling to in turn upregulate DAF-7 and insulin-like …

… & G. Ruvkun, unpublished data), making it unlikely that transcription or stability is altered.
Additionally, lin-14 mRNA remains associated with polyribosomes even after LIN-14 protein …

The Caenorhabditis elegans genome sequence was surveyed for transcription factor and
signaling gene families that have been shown to regulate development in a variety of species. …

In mammals, insulin signalling regulates glucose transport together with the expression and
activity of various metabolic enzymes. In the nematode Caenorhabditis elegans, a related …

The C. elegans heterochronic gene pathway consists of a cascade of regulatory genes that
are temporally controlled to specify the timing of developmental events 1 . Mutations in …

MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are
processed by Dicer from precursors with a characteristic hairpin secondary structure. …

… substitution of a G::U base pair for the G::C base pair in a lin-4(ma767)-h-74(+)+) RNA duplex
… single A to G mutation at position 20808, which substitutes a G:U base pair for an A:U base …

Two small RNAs regulate the timing of Caenorhabditis elegans development 1 , 2 . Transition
from the first to the second larval stage fates requires the 22-nucleotide lin-4 RNA 1 , 3 , 4 , …

… elegans Genetics Center, and the Ruvkun and Kaplan labs for assistance. KDK is supported
by the Japanese Society for the Promotion of Science. This work was supported by NIH …

RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves
the generation of 21 to 26 nt RNA segments that guide mRNA destruction. In …