An increasing body of evidence from animal models, human specimens and cell lines
points to reactive oxygen species as likely involved in the pathways, which convey both …

In the liver, the progressive accumulation of connective tissue, a complex and dynamic process
termed fibrosis, represents a very frequent event following a repeated or chronic insult of …

Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular
and cellular dysfunction that plays a major role in ageing and most age-related and …

… After overnight fast, we performed GTTs by intraperitoneal injection of 1.5 g/kg body weight
of dextrose (Abbott Laboratories). We drew blood samples at 0, 15, 30, 60, 90, and 120 min …

1. Methods using tlc and high-pressure liquid chromatography (hplc) have been used to
separate the complex variety of substances possessing a carbonyl function that are produced …

A comprehensive focus on 4‐hydroxynonenal (HNE) as candidate molecule in a variety of
pathophysiological conditions occurring in humans is here provided. Despite an active, now …

Various chronic disease processes are characterized by progressive accumulation of
connective tissue undergoing fibrotic degeneration. Evidence of oxidative reactions is often …

… centrifuged at 2000 x g for 2 min. after which supernatant and dead cell debris were re- …
After centrifugation for 2 min at 10,000 X g. supernatants were removed and tested for biologic …

… In fact, we have also observed IL6 production in infected primary macrophage cultures (Poli,
G., JS Justement, A. Kinter, and AS Fauci, unpublished observations). Furthermore, …

… Aliquots of the homogenates were added with an eaual volume of acetonitril and
subsequently centrifuged at 5000 g for 15 min at 0-4C. The supernatants were utilized for the …