… /100 g) and … g) for anthocyanins, soy products (148–466 mg/100 g) for isoflavonoids, spinach
and onions (119–158 mg/100 g) for flavonols, black olives and artichokes (27–58 mg/100 g…

The 1,5-diarylpyrrole derivative BM212 was previously shown to be active against multidrug-resistant
clinical isolates and Mycobacterium tuberculosis residing within macrophages as …

… Acute and chronic toxicity in mice (1 g/kg and 0.5 g/kg respectively) were found to be higher
than the therapeutic dose [93]. In a mouse model of chronic infection the minimal efficacious …

… , depending on the G protein-coupled type. While A 1 and A 3 are coupled with G i -proteins
(… ), A 2A and A 2B are coupled with G s -proteins (mediating the activation of adenylyl cyclase…

… (H) Fluorescence intensity per unit area for individual spheroplasts (n = 100) in each condition
in E–G is plotted, with the medians and interquartile ranges indicated. Mann–Whitney test: …

On the basis of suggestions derived either from a pharmacophoric model for antitubercular
agents or from a structure−activity relationship analysis of many pyrroles previously …

1,5-Diphenyl pyrroles were previously identified as a class of compounds endowed with high
in vitro efficacy against M. tuberculosis. To improve the physical chemical properties and …

… To a solution of 5 (7.8 g, 35 mmol) in methanol (150 mL), a solution of oxone (37.7 g, 61.4
mmol) in water (150 mL) was added over 5 min. After being stirred at 25 C for 2 h, the reaction …

Synthesis and biological evaluation of new derivatives of 1,5-bis(4-chlorophenyl)-2-methyl-3-(4-methylpiperazin-1-yl)methyl-1H-pyrrole
(BM 212, 16) are reported. Variously substituted …

Mycobacterium tuberculosis is responsible for about 9 million new tuberculosis (TB) cases
per year and 2 billion latent TB infections (LTBI) worldwide. 1, 2 Most of active TB is owing to …