User profiles for G. McVicker

Graham McVicker

Associate Professor, Salk Institute
Verified email at salk.edu
Cited by 5432

An overview of Ensembl

…, S Keenan, H Lehvaslaiho, G McVicker… - Genome …, 2004 - genome.cshlp.org
Ensembl ( http://www.ensembl.org/ ) is a bioinformatics project to organize biological
information around the sequences of large genomes. It is a comprehensive source of stable …

[PDF][PDF] Impact of genetic polymorphisms on human immune cell gene expression

…, B Ha, G Altay, JA Greenbaum, G McVicker, G Seumois… - Cell, 2018 - cell.com
While many genetic variants have been associated with risk for human diseases, how these
variants affect gene expression in various cell types remains largely unknown. To address …

The Ensembl core software libraries

A Stabenau, G McVicker, C Melsopp, G Proctor… - Genome …, 2004 - genome.cshlp.org
… This was originally developed as an output format from Exonerate (G. Slater, unpubl.)
and is known by its original acronym “cigar” (concise idiosyncratic gapped alignment report). …

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

…, DD Gonda, ML Levy, MG Rosenfeld, G McVicker… - Science, 2019 - science.org
Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation
is challenging. To better understand common genetic variation associated with brain …

Ensembl 2005

…, D London, I Longden, G McVicker… - Nucleic acids …, 2005 - academic.oup.com
The Ensembl ( http://www.ensembl.org/ ) project provides a comprehensive and integrated
source of annotation of large genome sequences. Over the last year the number of genomes …

WASP: allele-specific software for robust molecular quantitative trait locus discovery

B Van De Geijn, G McVicker, Y Gilad, JK Pritchard - Nature methods, 2015 - nature.com
… where G im is the genotype of individual i at test SNP m, and T i is the total number of reads
… Bryce van de Geijn and Graham McVicker: These authors contributed equally to this work. …

Identification of genetic variants that affect histone modifications in human cells

G McVicker, B Van De Geijn, JF Degner, CE Cain… - Science, 2013 - science.org
Histone modifications are important markers of function and chromatin state, yet the DNA
sequence elements that direct them to specific genomic locations are poorly understood. Here, …

[HTML][HTML] Widespread genomic signatures of natural selection in hominid evolution

G McVicker, D Gordon, C Davis, P Green - PLoS genetics, 2009 - journals.plos.org
… This column could be the result of a single A→G transition substitution on … →G transitions
on both H and G branches, or an A→G transition on the HCG branch and a back substitution (G

Selective ring opening of naphthenic molecules

GB McVicker, M Daage, MS Touvelle, CW Hudson… - Journal of …, 2002 - Elsevier
Ring opening as practiced in hydrocracking of naphthenic molecules results from multiple
cleavages of both endo- and exocyclic C–C bonds. Selective ring opening requires that only …

[HTML][HTML] Controls of nucleosome positioning in the human genome

DJ Gaffney, G McVicker, AA Pai… - PLoS …, 2012 - journals.plos.org
Nucleosomes are important for gene regulation because their arrangement on the genome
can control which proteins bind to DNA. Currently, few human nucleosomes are thought to …