The Drosophila eye is an outstanding model with which to decipher mechanisms of neural
differentiation. Paramount to normal eye development is the organized selection and …

The presence or absence of the Y chromosome determines whether a mammalian embryo
develops as a male or female. In humans, genetic deletion analysis of "sex-reversed" …

… A side view of a leg disc similar to that in F is shown in G. The arrow in G indicates the portion
of the disc fated to give rise to the distal tarsal segments and claw of the adult leg. Ventral …

Mutations in the gene parkin in humans (PARK2) are responsible for a large number of
familial cases of autosomal-recessive Parkinson disease. We have isolated a Drosophila …

… Moreover, mouse Dach2 (isolated in a screen using the chick Dach2 probe; G. Mardon,
unpubl.) is expressed normally in Pax3 (Splotch; Epstein et al. 1991) mutant mouse embryos (T. …

The eyeless, dachshund, and eyes absent genes encode conserved, nuclear proteins that
are essential for eye development in Drosophila. Misexpression of eyeless or dachshund is …

The dachshund (dac) gene was initially described as a mutant phenotype in flies featuring
extremely short legs relative to their body length. Functioning as a dominant suppressor of the …

The Eyes absent proteins are members of a conserved regulatory network implicated in the
development of the eye, muscle, kidney and ear 1 , 2 , 3 , 4 , 5 , 6 , 7 . Mutations in the Eyes …

Leber congenital amaurosis (LCA) is a blinding retinal disease that presents within the first
year after birth. Using exome sequencing, we identified mutations in the nicotinamide …

The dachshund gene encodes a nuclear protein that is required for normal eye development
in Drosophila. In the absence of dachshund function, flies develop with severely reduced or …