MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …

Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML) have
revealed a striking heterogeneity with regard to the presence of acquired gene mutations …

Recent molecular analyses of leukemic blasts from pretreatment marrow or blood of patients
with acute myeloid leukemia (AML) and a normal karyotype, the largest cytogenetic subset (…

MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes.
Recent studies suggest roles of miRNAs in carcinogenesis. We and others have shown that …

Background Patients with acute myeloid leukemia (AML) and a FLT3 mutation have poor
outcomes. We conducted a phase 3 trial to determine whether the addition of midostaurin — an …

Background Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, …

MicroRNAs (miRNAs) are small RNAs of 19 to 25 nucleotides that are negative regulators of
gene expression. To determine whether miRNAs are associated with cytogenetic …

B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell death at the
mitochondrion. It remains a challenge to identify those tumors that are best treated by …

… Patients on CALGB 9420 received postremission therapy with cytarabine (2 g/m 2 /d) alone,
and patients on CALGB 9720 received a single cytarabine/daunorubicin consolidation course …

Aberrant DNA hypermethylation contributes to myeloid leukemogenesis by silencing structurally
normal genes involved in hematopoiesis. MicroRNAs (miRNAs) are noncoding RNAs …