User profiles for G. Innocentini

Guilherme Innocentini

IME-USP
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Cited by 511

Self-regulating gene: an exact solution

JEM Hornos, D Schultz, GCP Innocentini, J Wang… - Physical Review E, 2005 - APS
An exact steady-state solution of the stochastic equations governing the behavior of a gene
regulated by a self-generated proteomic atmosphere is presented. The solutions depend on …

Symmetry in biology: from genetic code to stochastic gene regulation

AF Ramos, GCP Innocentini, FM Forger, JEM Hornos - IET systems biology, 2010 - IET
… It is composed of (n × n)-matrices g which are orthogonal, that is, satisfy g T g = 1 (where g
T denotes the transpose of g), and have determinant 1. The concrete form of such a matrix in …

Exact time-dependent solutions for a self-regulating gene

AF Ramos, GCP Innocentini, JEM Hornos - Physical Review E, 2011 - APS
The exact time-dependent solution for the stochastic equations governing the behavior of a
binary self-regulating gene is presented. Using the generating function technique to …

Modeling stochastic gene expression under repression

GCP Innocentini, JEM Hornos - Journal of Mathematical Biology, 2007 - Springer
Intrinsic transcriptional noise induced by operator fluctuations is investigated with a simple
spin-like stochastic model. The effects of transcriptional fluctuations in protein synthesis are …

Multimodality and flexibility of stochastic gene expression

GCP Innocentini, M Forger, AF Ramos… - Bulletin of mathematical …, 2013 - Springer
We consider a general class of mathematical models for stochastic gene expression where
the transcription rate is allowed to depend on a promoter state variable that can take an …

Protein synthesis driven by dynamical stochastic transcription

GCP Innocentini, M Forger, O Radulescu… - Bulletin of mathematical …, 2016 - Springer
… where F and G are arbitrary functions that must be determined from the initial conditions, …
In order to determine F and G we will use matrix and vector notation to rewrite the solutions of Eq…

Relating network rigidity, time scale hierarchies, and expression noise in gene networks

O Radulescu, GCP Innocentini, JEM Hornos - Physical Review E, 2012 - APS
… When XD = 1, proteins are produced with rate g and degraded with rate kn. When XD = 0,
production falls to χg,χ < 1. The transition between active and inactive states is commanded by …

[HTML][HTML] Time dependent stochastic mRNA and protein synthesis in piecewise-deterministic models of gene networks

GCP Innocentini, A Hodgkinson, O Radulescu - Frontiers in Physics, 2018 - frontiersin.org
We discuss piecewise-deterministic approximations of gene networks dynamics. These
approximations capture in a simple way the stochasticity of gene expression and the …

[HTML][HTML] Comment on “Steady-state fluctuations of a genetic feedback loop: An exact solution”[J. Chem. Phys. 137, 035104 (2012)]

GCP Innocentini, AF Ramos… - The Journal of chemical …, 2015 - pubs.aip.org
… In fact, they present an exact general solution for one of the generating functions named
G 1 (z), but they fail to get G 0 (z) in closed form, as they explicitly recognize. Therefore, the …

Time-inhomogeneous random Markov chains

GCP Innocentini, M Novaes - Journal of Statistical Mechanics …, 2018 - iopscience.iop.org
We consider Markov chains with random transition probabilities which, moreover, fluctuate
randomly with time. We describe such a system by a product of stochastic matrices,, with the …