User profiles for G. Heap
 | Graham HeapRoyal Devon & Exeter NHS Trust, University of Exeter Verified email at exeter.ac.uk Cited by 8268 |
The pattern and outcome of acute severe colitis
Background: The prognosis of acute severe ulcerative colitis (ASC) influences therapeutic
decisions, but data on prevalence or long-term outcome are few. Methods: A systematic …
decisions, but data on prevalence or long-term outcome are few. Methods: A systematic …
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Genetic association studies have identified 215 risk loci for inflammatory bowel disease 1 ,
2 , 3 , 4 , 5 , 6 , 7 , 8 , thereby uncovering fundamental aspects of its molecular biology. We …
2 , 3 , 4 , 5 , 6 , 7 , 8 , thereby uncovering fundamental aspects of its molecular biology. We …
Multiple common variants for celiac disease influencing immune gene expression
…, J Romanos, A Curtotti, A Zhernakova, GAR Heap… - Nature …, 2010 - nature.com
We performed a second-generation genome-wide association study of 4,533 individuals with
celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with …
celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with …
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Using variants from the 1000 Genomes Project pilot European CEU dataset and data from
additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously …
additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously …
[HTML][HTML] Shared and distinct genetic variants in type 1 diabetes and celiac disease
Background Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in
populations, suggesting a common genetic origin. Since both diseases are associated with …
populations, suggesting a common genetic origin. Since both diseases are associated with …
Newly identified genetic risk variants for celiac disease related to the immune response
KA Hunt, A Zhernakova, G Turner, GAR Heap… - Nature …, 2008 - nature.com
Our genome-wide association study of celiac disease previously identified risk variants in
the IL2–IL21 region. To identify additional risk variants, we genotyped 1,020 of the most …
the IL2–IL21 region. To identify additional risk variants, we genotyped 1,020 of the most …
Genetics and pathogenesis of coeliac disease
GA Heap, DA van Heel - Seminars in immunology, 2009 - Elsevier
Coeliac disease is a common complex disease caused by a dietary intolerance to wheat
gluten. Susceptibility is determined by both environmental and genetic factors. Coeliac disease …
gluten. Susceptibility is determined by both environmental and genetic factors. Coeliac disease …
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …
[HTML][HTML] HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's disease
… Heap reports non-financial support from AbbVie, outside the submitted work; and he is
now an employee of AbbVie and owns stock in the company. Mark Reppell is an employee of …
now an employee of AbbVie and owns stock in the company. Mark Reppell is an employee of …
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility
…, D Graham, E Hämäläinen, T Haritunians, GA Heap… - Nature …, 2022 - nature.com
Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn’s disease (CD). However, as with all complex diseases, robust identification of the …
Crohn’s disease (CD). However, as with all complex diseases, robust identification of the …