User profiles for G. Davey Smith
George Davey SmithUniversity of Bristol Verified email at bristol.ac.uk Cited by 411176 |
The MR-Base platform supports systematic causal inference across the human phenome
… A SNP with (for example) effect/non-effect alleles G/T for the exposure and T/G for the … SNPs
that are reported as (for example) G/T for the exposure summary dataset and C/A for the out…
that are reported as (for example) G/T for the exposure summary dataset and C/A for the out…
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
…, W Zhang, B Hedblad, P Nilsson, G Davey Smith… - Nature, 2011 - nature.com
Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
G Davey Smith, G Hemani - Human molecular genetics, 2014 - academic.oup.com
Observational epidemiological studies are prone to confounding, reverse causation and
various biases and have generated findings that have proved to be unreliable indicators of the …
various biases and have generated findings that have proved to be unreliable indicators of the …
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
…, DA Lawlor, Y Ben-Shlomo, G Davey-Smith… - Nature …, 2008 - nature.com
To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals …
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals …
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
J Bowden, G Davey Smith… - International journal of …, 2015 - academic.oup.com
Background: The number of Mendelian randomization analyses including large numbers of
genetic variants is rapidly increasing. This is due to the proliferation of genome-wide …
genetic variants is rapidly increasing. This is due to the proliferation of genome-wide …
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
G Davey Smith, S Ebrahim - International journal of …, 2003 - academic.oup.com
… 11 with fibrinogen levels of 3.10 g/l in G/G individuals, 3.22 g/l in A/G individuals, and 3.36
g/l in A/A individuals. For each A allele there was an increase of 0.12 g/l in fibrinogen. In this …
g/l in A/A individuals. For each A allele there was an increase of 0.12 g/l in fibrinogen. In this …
Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator
… (Davey Smith and Ebrahim, 2005; Nitsch et al., 2006). If the randomization is indeed
uncontaminated (in the sense that a person's genetic subgroup is independent of all factors, except …
uncontaminated (in the sense that a person's genetic subgroup is independent of all factors, except …
Identification of common genetic risk variants for autism spectrum disorder
…, S Sandin, FK Satterstrom, G Davey Smith… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …
Mendelian randomization: using genes as instruments for making causal inferences in epidemiology
… Lewis SJ, Harbord RM, Harris R, Davey Smith G. Meta-analyes of observational and genetic
association studies of folate intakes or levels and breast cancer risk. Journal of National …
association studies of folate intakes or levels and breast cancer risk. Journal of National …
Cohort profile: the 'children of the 90s'—the index offspring of the Avon Longitudinal Study of Parents and Children
…, A Ness, S Ring, G Davey Smith - International journal …, 2013 - academic.oup.com
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational
prospective observational study investigating influences on health and development across the …
prospective observational study investigating influences on health and development across the …