Background: Common cancers develop through a multistep process often including inherited
susceptibility. Collaboration among multiple institutions, and funding from multiple sources, …

… Diagnostic Criteria The diagnostic criteria were modifications of those used by Chenevix-Trench
et al. [19931. One member of each family was required to have two of four major …

Epithelial ovarian cancer (EOC) is often a lethal disease because in many cases early
symptoms go undetected. Although research proceeds apace, as yet there are few reliable and …

… a, b, Conservation of amino acid sequence for the activation segment (a) and G loop (b). The
positions of mutations are indicated by yellow shading; V599 is denoted by an asterisk. The …

Cancers arise owing to mutations in a subset of genes that confer growth advantage. The
availability of the human genome sequence led us to propose that systematic resequencing of …

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

The nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder
characterized by multiple basal cell carcinomas (BCCs), pits of the palms and soles, jaw …

The protein-kinase family is the most frequently mutated gene family found in human cancer
and faulty kinase enzymes are being investigated as promising targets for the design of …

Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors. …

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