Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …

A substantial proportion of the genome of many species is derived from transposable elements
(TEs). Moreover, through various self-copying mechanisms, TEs continue to proliferate in …

Repetitive DNA and in particular transposable elements have been intimately linked to
eukaryotic genomes for millions of years. Once overlooked for being only a collection of selfish …

We present a new update to MetaboAnalyst (version 4.0) for comprehensive metabolomic
data analysis, interpretation, and integration with other omics data. Since the last major update …

Genomes are organized into high-level three-dimensional structures, and DNA elements
separated by long genomic distances can in principle interact functionally. Many transcription …

Oct4 and Nanog are transcription factors required to maintain the pluripotency and self-renewal
of embryonic stem (ES) cells. Using the chromatin immunoprecipitation paired-end …

Transcription factors (TFs) and their specific interactions with targets are crucial for specifying
gene-expression programs. To gain insights into the transcriptional regulatory networks in …

Here the Human Pangenome Reference Consortium presents a first draft of the human
pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of …

Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are
devastating brain tumors with no effective therapy. Here, we investigated clinical and biological …