Background Hereditary cancer predisposition syndromes are responsible for approximately
5–10% of all diagnosed cancer cases. In the past, single-gene analysis of specific high risk …

… TSAOUSIS, KEVISA POTSKA, DIMITRA BOUZARELOU, ANASTASIA KATSELI, CHRISTINA
… EP and GN conceived of the study and participated in its design and coordination. All …

Objective Several microRNA (miRNA) polymorphisms have been associated with susceptibility
to specific health disorders, including cardiovascular diseases. The aim of the present …

Molecular Recognition Features (MoRFs) are defined as short, intrinsically disordered
regions in proteins that undergo disorder-to-order transition upon binding to their partners. As …

A large number of modular domains that exhibit specific lipid binding properties are present
in many membrane proteins involved in trafficking and signal transduction. These domains …

Alternative splicing (AS), a crucial cellular process, is a source of transcriptomic expansion
and protein variability. Its contribution to cancer development and progression among a vast …

Background: Classification of splicing variants (SVs) in genes associated with hereditary
cancer is often challenging. The aim of this study was to investigate the occurrence of SVs in …

During the last two decades a large number of computational methods have been developed
for predicting transmembrane protein topology. Current predictors rely on topogenic …

… Tsaousis a , Eirini Papadopoulou a , Vasiliki Metaxa-Mariatou a , Angeliki Tsirigoti a , Chrysoula
Efstathiadou a , Christos Markopoulos b , Grigorios Xepapadakis c , Vasileios Venizelos …

The majority of all proteins in cells interact with membranes either permanently or temporarily.
Peripheral membrane proteins form transient complexes with membrane proteins and/or …