Cross‐presentation involves the uptake and processing of exogenous antigens within the
major histocompatibility complex (MHC) class I pathway. This process is primarily performed …

Suppressor of cytokine signalling‐1 (SOCS1), as the name implies, is a protein that functions
as a negative regulator of cytokine signalling. Initially characterized for its ability to inhibit …

A novel dendritic cell (DC)–restricted molecule, Clec9A, was identified by gene expression
profiling of mouse DC subtypes. Based on sequence similarity, a human ortholog was …

In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

… We have also analyzed GM-DCs, but again we could only … However, comparing the protocols
for the generation of GM-… It is known that inflammatory cytokines such as IFN-Is, IFN-γ, GM-…

To better understand the antigenic requirements for cross-presentation, we compared the in
vivo efficiency of presentation of cell-associated vs soluble OVA with the OT-I (CD8) and OT-…

Three surface molecules of mouse CD8+ dendritic cells (DCs), also found on the equivalent
human DC subpopulation, were compared as targets for Ab-mediated delivery of Ags, a …

During T cell development, thymocytes which are tolerant to self-peptides but reactive to
foreign peptides are selected. The current model for thymocyte selection proposes that self-…

To investigate the role of Aire in thymic selection, we examined the cellular requirements for
generation of ovalbumin (OVA)–specific CD4 and CD8 T cells in mice expressing OVA …

Although CD8 + T cells do not contribute to protection against the blood stage of
Plasmodium infection, there is mounting evidence that they are principal mediators of murine …