The gut microbiota is a complex and plastic network of diverse organisms intricately connected
with human physiology. Recent advances in profiling approaches of both the microbiota …

Diet modulates the gut microbiome, which in turn can impact the immune system. Here, we
determined how two microbiota-targeted dietary interventions, plant-based fiber and …

… We would like to thank members of the Fragiadakis lab, the UCSF Bakar ImmunoX Initiative,
and the UCSF CoLabs for discussion and guidance for this review. We would like to thank Dr…

Neutralizing autoantibodies against type I interferons (IFNs) have been found in some patients
with critical coronavirus disease 2019 (COVID-19), the disease caused by severe acute …

Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
pleiotropic and systemic effects in some individuals 1 , 2 – 3 , many others experience …

Low-grade, chronic inflammation has been associated with many diseases of aging, but the
mechanisms responsible for producing this inflammation remain unclear. Inflammasomes …

Delayed recovery from surgery causes personal suffering and substantial societal and economic
costs. Whether immune mechanisms determine recovery after surgical trauma remains …

INTRODUCTION Immune cells constitute an interacting hierarchy that coordinates its activities
according to genetic and environmental contexts. This systemically mobile network of …

Cancers display significant heterogeneity with respect to tissue of origin, driver mutations,
and other features of the surrounding tissue. It is likely that individual tumors engage common …

Background Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic,
there has been increasing urgency to identify pathophysiological characteristics leading to …