Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic
abnormalities in which the individual components of the phenotype are observed and …

There are two basic types of bacterial communication systems—those in which the signal is
directed solely at other organisms and those in which the signal is sensed by the producing …

Generations of chemists and biologists have conducted research on natural products and
other metabolites produced by bacteria and other microorganisms. This has led to an …

Importance Tourette syndrome (TS) is characterized by high rates of psychiatric comorbidity;
however, few studies have fully characterized these comorbidities. Furthermore, most …

Background To facilitate the clinical implementation of genomic medicine by next-generation
sequencing, it will be critically important to obtain accurate and consistent variant calls on …

Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric
disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) …

The staphylococcal virulon is activated by the density-sensingagr system, which is autoinduced
by a short peptide (autoinducing peptide [AIP]) processed from a propeptide encoded …

We develop a statistical tool SNVer for calling common and rare variants in analysis of pooled
or individual next-generation sequencing (NGS) data. We formulate variant calling as a …

Two-component signaling systems involving receptor-histidine kinases are ubiquitous in
bacteria and have been found in yeast and plants. These systems provide the major means by …

Many monogenic disorders cause a characteristic facial morphology. Artificial intelligence can
support physicians in recognizing these patterns by associating facial phenotypes with the …