User profiles for G. J. Lyon
Gholson LyonInstitute for Basic Research in Developmental Disabilities Verified email at opwdd.ny.gov Cited by 11447 |
The human phenotype ontology in 2017
Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic
abnormalities in which the individual components of the phenotype are observed and …
abnormalities in which the individual components of the phenotype are observed and …
Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria
GJ Lyon, RP Novick - Peptides, 2004 - Elsevier
There are two basic types of bacterial communication systems—those in which the signal is
directed solely at other organisms and those in which the signal is sensed by the producing …
directed solely at other organisms and those in which the signal is sensed by the producing …
[PDF][PDF] Chemical signaling among bacteria and its inhibition
Generations of chemists and biologists have conducted research on natural products and
other metabolites produced by bacteria and other microorganisms. This has led to an …
other metabolites produced by bacteria and other microorganisms. This has led to an …
Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome
Importance Tourette syndrome (TS) is characterized by high rates of psychiatric comorbidity;
however, few studies have fully characterized these comorbidities. Furthermore, most …
however, few studies have fully characterized these comorbidities. Furthermore, most …
[HTML][HTML] Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing
Background To facilitate the clinical implementation of genomic medicine by next-generation
sequencing, it will be critically important to obtain accurate and consistent variant calls on …
sequencing, it will be critically important to obtain accurate and consistent variant calls on …
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric
disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) …
disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) …
Exfoliatin-Producing Strains Define a Fourthagr Specificity Group in Staphylococcus aureus
S Jarraud, GJ Lyon, AMS Figueiredo… - Journal of …, 2000 - Am Soc Microbiol
The staphylococcal virulon is activated by the density-sensingagr system, which is autoinduced
by a short peptide (autoinducing peptide [AIP]) processed from a propeptide encoded …
by a short peptide (autoinducing peptide [AIP]) processed from a propeptide encoded …
SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data
We develop a statistical tool SNVer for calling common and rare variants in analysis of pooled
or individual next-generation sequencing (NGS) data. We formulate variant calling as a …
or individual next-generation sequencing (NGS) data. We formulate variant calling as a …
Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine …
Two-component signaling systems involving receptor-histidine kinases are ubiquitous in
bacteria and have been found in yeast and plants. These systems provide the major means by …
bacteria and have been found in yeast and plants. These systems provide the major means by …
GestaltMatcher facilitates rare disease matching using facial phenotype descriptors
…, HB Bentzen, L Averdunk, KC Coetzer, GJ Lyon… - Nature …, 2022 - nature.com
Many monogenic disorders cause a characteristic facial morphology. Artificial intelligence can
support physicians in recognizing these patterns by associating facial phenotypes with the …
support physicians in recognizing these patterns by associating facial phenotypes with the …