Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often
ineffective, and predictive biomarkers to guide treatment are urgently needed. We …

The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and
a potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …

Intratumoral heterogeneity is a critical frontier in understanding how the tumor microenvironment
(TME) propels malignant progression. Here, we deconvolute the human pancreatic …

Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis,
exemplifies the classically held view of stepwise cancer development 1 . The current model of …

Purpose: To perform real-time whole genome sequencing (WGS) and RNA sequencing (RNASeq)
of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive …

Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in patients.
The basis of this disease heterogeneity has proved difficult to resolve due to poor tumor …

Tumors often contain multiple subpopulations of cancerous cells defined by distinct somatic
mutations. We describe a new method, PhyloWGS, which can be applied to whole-genome …

Preclinical screening with animal models is an important initial step in clinical translation of
new drug delivery systems. However, establishing efficacy, biodistribution, and biotoxicity of …

Purpose: To determine the impact of basal-like and classical subtypes in advanced
pancreatic ductal adenocarcinoma (PDAC) and to explore GATA6 expression as a surrogate …

Importance Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain
poor. Advances in next-generation sequencing provide a route to therapeutic approaches, …