Background Fibroglandular breast tissue appears dense on mammogram, whereas fat
appears nondense. It is unclear whether absolute or percentage dense area more strongly …

Background: Common cancers develop through a multistep process often including inherited
susceptibility. Collaboration among multiple institutions, and funding from multiple sources, …

Background Body mass index (BMI), a measure of obesity typically assessed in middle age
or later, is known to be positively associated with pancreatic cancer. However, little evidence …

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

Objective To assess the cancer risk in children and adolescents following exposure to low
dose ionising radiation from diagnostic computed tomography (CT) scans. Design Population …

The vast majority of coding variants are rare, and assessment of the contribution of rare
variants to complex traits is hampered by low statistical power and limited functional data. …

Background In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut
mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic …

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for ∼9…

Background Immunohistochemical markers are often used to classify breast cancer into
subtypes that are biologically distinct and behave differently. The aim of this study was to …