Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to
DNA, and chemical modification of histones is a major means by which the cell modulates …

Epigenetic regulation of gene enhancer elements is important for establishing and maintaining
the identity of cells. Gene enhancer elements are thought to exist in either active or …

Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome - Zentner - 2010
… How to cite this article: Zentner GE, Layman WS, Martin DM, Scacheri PC. 2010. Molecular …

CHD7 is a member of the chromodomain helicase DNA binding domain family of ATP-dependent
chromatin remodeling enzymes. De novo mutation of the CHD7 gene is a major cause …

Recent human decedent model studies 1 , 2 and compassionate xenograft use 3 have explored
the promise of porcine organs for human transplantation. To proceed to human studies, …

Sequence-specific DNA-binding proteins including transcription factors (TFs) are key determinants
of gene regulation and chromatin architecture. TF profiling is commonly carried out by …

Naive mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs)
represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and …

The transcription of ribosomal RNA (rRNA) is critical to life. Despite its importance, ribosomal
DNA (rDNA) is not included in current genome assemblies and, consequently, genomic …

The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function
together to shape chromatin architecture in mammalian cells, but the molecular details of this …

Chromatin endogenous cleavage (ChEC) uses fusion of a protein of interest to micrococcal
nuclease (MNase) to target calcium-dependent cleavage to specific genomic loci in vivo. …