Stem cells are unique in their ability to self-renew and differentiate into various cell types.
Because of these features, stem cells are key to the formation of organisms and play …

Background The discovery that somatic cells can be reprogrammed to induced pluripotent
stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug …

There are currently no treatments for geographic atrophy, the advanced form of age-related
macular degeneration. Hence, innovative studies are needed to model this condition and …

Optic neuropathies are characterised by a loss of retinal ganglion cells (RGCs) that lead to
vision impairment. Development of cell therapy requires a better understanding of the signals …

Precision genome engineering has dramatically advanced with the development of CRISPR/Cas
base editing systems that include cytosine base editors and adenine base editors (…

Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a
major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or …

We demonstrate that a combination of Noggin, Dickkopf-1, Insulin Growth Factor 1 and basic
Fibroblast Growth Factor, promotes the differentiation of human pluripotent stem cells into …

Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest
including the cells of the retina and optic nerve. These cells can then be used to study …

The mechanisms by which DNA alleles contribute to disease risk, drug response, and other
human phenotypes are highly context-specific, varying across cell types and different …

Patient-specific induced pluripotent stem cells (iPSCs) have tremendous potential for
development of regenerative medicine, disease modeling, and drug discovery. However, the …