User profiles for G. B. Mills

Gordon Mills

Oregon Health & Science University
Verified email at ohsu.edu
Cited by 273094

Exploiting the PI3K/AKT pathway for cancer drug discovery

…, DL Smith, PT Ram, Y Lu, GB Mills - Nature reviews Drug …, 2005 - nature.com
Evolving studies with several different targeted therapeutic agents are demonstrating that
patients with genomic alterations of the target, including amplification, translocation and …

The biology of ovarian cancer: new opportunities for translation

RC Bast Jr, B Hennessy, GB Mills - Nature Reviews Cancer, 2009 - nature.com
Over the past two decades, the 5-year survival for ovarian cancer patients has substantially
improved owing to more effective surgery and treatment with empirically optimized …

The emerging role of lysophosphatidic acid in cancer

GB Mills, WH Moolenaar - Nature Reviews Cancer, 2003 - nature.com
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation,
migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA …

[HTML][HTML] Inferring tumour purity and stromal and immune cell admixture from expression data

…, SL Carter, G Getz, K Stemke-Hale, GB Mills… - Nature …, 2013 - nature.com
Infiltrating stromal and immune cells form the major fraction of normal cells in tumour tissue
and not only perturb the tumour signal in molecular studies but also have an important role in …

[HTML][HTML] The cancer genome atlas pan-cancer analysis project

JN Weinstein, EA Collisson, GB Mills, KR Shaw… - Nature …, 2013 - nature.com
The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large
numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and …

[HTML][HTML] The somatic genomic landscape of glioblastoma

…, CM Perou, DN Hayes, R Gibbs, M Marra, GB Mills… - cell, 2013 - cell.com
We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …

Use of proteomic patterns in serum to identify ovarian cancer

…, BA Hitt, PJ Levine, VA Fusaro, SM Steinberg, GB Mills… - The lancet, 2002 - thelancet.com
… E Kohn, D Fishman, C Simone, and G Mills designed and wrote the participants section,
provided serum sets used in the study, and assisted in the preparation of the paper. A Ardekani …

[PDF][PDF] The immune landscape of cancer

…, A Korkut, J Li, H Liang, S Ling, W Liu, Y Lu, GB Mills… - Immunity, 2018 - cell.com
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

KE O'Reilly, F Rojo, QB She, D Solit, GB Mills, D Smith… - Cancer research, 2006 - AACR
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the
phosphoinositide-3-kinase/Akt/mTOR pathway causing pleiotropic cellular effects including an …

[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics

…, A Korkut, J Li, H Liang, S Ling, W Liu, Y Lu, GB Mills… - Cell, 2018 - cell.com
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …