… Kuchel is supported in part by a grant from the Patrick and … Kuchel has served as a
consultant for Johnson and Johnson, … George Kuchel: study concept and design, analysis and …

Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming during …

Over the last decade there has been an enormous expansion of research focused on
defining the role of inflammation in aging, age-related diseases, disability, and frailty. The …

Background Hospitalized COVID-19 patients tend to be older and frequently have
hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true risk …

The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and
shortness of breath being common. In older adults, we found that preexisting dementia is a …

… Zhou, Xin a,b ; Fragala, Maren S a ; McElhaney, Janet E a,b ; Kuchel, George A a …
Kuchel, MD, UConn Center on Aging, University of Connecticut Health Center, 263 …

Differences in immune function and responses contribute to health- and life-span disparities
between sexes. However, the role of sex in immune system aging is not well understood. …

Senescent cells are highly associated with aging and pathological conditions and could be
targeted to slow the aging process. One commonly used marker to examine senescent cells …

Aging is often accompanied by declines in physical functioning which impedes older adults’
quality of life, sense of independence, and ability to perform daily tasks. Age-related …

Insulin resistance is a pathological state often associated with obesity, representing a major
risk factor for type 2 diabetes. Limited mechanism-based strategies exist to alleviate insulin …