[HTML][HTML] Human cytomegalovirus vaccine based on the envelope gH/gL pentamer complex
F Wussow, F Chiuppesi, J Martinez, J Campo… - PLoS …, 2014 - journals.plos.org
Human Cytomegalovirus (HCMV) utilizes two different pathways for host cell entry. HCMV
entry into fibroblasts requires glycoproteins gB and gH/gL, whereas HCMV entry into epithelial …
entry into fibroblasts requires glycoproteins gB and gH/gL, whereas HCMV entry into epithelial …
[HTML][HTML] Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
…, Y Shostak, DJ Diamond, F Wussow - Nature …, 2020 - nature.com
Modified Vaccinia Ankara (MVA) is a highly attenuated poxvirus vector that is widely used to
develop vaccines for infectious diseases and cancer. We demonstrate the construction of a …
develop vaccines for infectious diseases and cancer. We demonstrate the construction of a …
A Self-Excisable Infectious Bacterial Artificial Chromosome Clone of Varicella-Zoster Virus Allows Analysis of the Essential Tegument Protein Encoded by ORF9
BK Tischer, BB Kaufer, M Sommer, F Wussow… - Journal of …, 2007 - Am Soc Microbiol
… (F. Wussow and BK Tischer, unpublished data). The combination of the VZV-BAC clone
at hand, the established techniques to perform markerless mutagenesis in E. coli, and the …
at hand, the established techniques to perform markerless mutagenesis in E. coli, and the …
[PDF][PDF] Modeling human cytomegalovirus-induced microcephaly in human iPSC-derived brain organoids
Although congenital infection by human cytomegalovirus (HCMV) is well recognized as a
leading cause of neurodevelopmental defects, HCMV neuropathogenesis remains poorly …
leading cause of neurodevelopmental defects, HCMV neuropathogenesis remains poorly …
Vaccine-derived neutralizing antibodies to the human cytomegalovirus gH/gL pentamer potently block primary cytotrophoblast infection
F Chiuppesi, F Wussow, E Johnson, C Bian… - Journal of …, 2015 - Am Soc Microbiol
Human cytomegalovirus (HCMV) elicits neutralizing antibodies (NAb) of various potencies
and cell type specificities to prevent HCMV entry into fibroblasts (FB) and epithelial/…
and cell type specificities to prevent HCMV entry into fibroblasts (FB) and epithelial/…
Maternal CD4+ T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission
…, F Chiuppesi, F Wussow… - Proceedings of the …, 2015 - National Acad Sciences
Elucidation of maternal immune correlates of protection against congenital cytomegalovirus
(CMV) is necessary to inform future vaccine design. Here, we present a novel rhesus …
(CMV) is necessary to inform future vaccine design. Here, we present a novel rhesus …
[HTML][HTML] Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised …
Background COH04S1, a synthetic attenuated modified vaccinia virus Ankara vector co-expressing
SARS-CoV-2 spike and nucleocapsid antigens, was tested for safety and …
SARS-CoV-2 spike and nucleocapsid antigens, was tested for safety and …
A vaccine based on the rhesus cytomegalovirus UL128 complex induces broadly neutralizing antibodies in rhesus macaques
F Wussow, Y Yue, J Martinez, JD Deere… - Journal of …, 2013 - Am Soc Microbiol
Neutralizing antibodies (NAb) are important for interfering with horizontal transmission of
human cytomegalovirus (HCMV) leading to primary and congenital HCMV infection. Recent …
human cytomegalovirus (HCMV) leading to primary and congenital HCMV infection. Recent …
MVA vaccine encoding CMV antigens safely induces durable expansion of CMV-specific T cells in healthy adults
…, M Carroll, F Wussow, F Chiuppesi… - Blood, The Journal …, 2017 - ashpublications.org
Attenuated poxvirus modified vaccinia Ankara (MVA) is a useful viral-based vaccine for
clinical investigation, because of its excellent safety profile and property of inducing potent …
clinical investigation, because of its excellent safety profile and property of inducing potent …
[HTML][HTML] Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates
…, H Andersen, MG Lewis, Y Shostak, F Wussow… - npj Vaccines, 2022 - nature.com
… Panels c, f, and i show viral loads by area under the curve (AUC). Violin plots show value
ranges with median values (dashed line) and quartiles (dotted line). AUC = 0 was indicated as …
ranges with median values (dashed line) and quartiles (dotted line). AUC = 0 was indicated as …