BACKGROUND: In many published studies, elastic properties of bone are correlated to the
bone density, in order to derive an empirical elasticity–density relationship. The most …

… A simulation model by Taddei et al. [20], modelling the adaptation of a finite population to
a new environment, took into account those beneficial mutations as well as deleterious and …

Bacteria with elevated mutation rates are frequently found among natural isolates. This is
probably because of their ability to generate genetic variability, the substrate for natural …

The quantitative study of the cell growth [1–5] has led to many fundamental insights in our
understanding of a wide range of subjects, from the cell cycle [6–9] to senescence [10]. Of …

BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia, and no current
therapy is ideal for control of this condition. Experimental studies suggest that angiotensin II-…

Because most newly arising mutations are neutral or deleterious, it has been argued 1 , 2 ,
3 that the mutation rate has evolved to be as low as possible, limited only by the cost of error-…

In macroscopic organisms, aging is often obvious; in single-celled organisms, where there
is the greatest potential to identify the molecular mechanisms involved, identifying and …

The evolutionary significance of stress-induced mutagenesis was evaluated by studying
mutagenesis in aging colonies (MAC) of Escherichia coli natural isolates. A large fraction of …

Aging, defined as a decrease in reproduction rate with age, is a fundamental characteristic
of all living organisms down to bacteria. Yet we know little about the causal molecular …

We have shown that bacterial mutation rates change during the experimental colonization
of the mouse gut. A high mutation rate was initially beneficial because it allowed faster …