Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

More than half of the world’s population now lives in cities, making the creation of a healthy
urban environment a major policy priority 1 . Cities have both health risks and benefits 1 , but …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

Minimal phenotyping refers to the reliance on the use of a small number of self-reported
items for disease case identification, increasingly used in genome-wide association studies (…

Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …

… Streit F. Estudo do aproveitamento do bagaço de maçã para produção de quitosana fúngica…
Vendruscolo F. Cultivo em meio sólido e submerso do bagaço de maçã por Gongronella …

Extracellular vesicles (EVs) are membrane particles secreted from cells into all body fluids.
Several EV populations exist differing in size and cellular origin. Using differential …

Background: Tacrolimus is metabolized predominantly to 13-O-demethyltacrolimus in the
liver and intestine by cytochrome P450 3A (CYP3A). Patients with high concentrations of …

Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified …