User profiles for F. Kondrashov

Fyodor A Kondrashov

Okinawa Institute of Science and Technology
Verified email at oist.jp
Cited by 11592

The evolution of gene duplications: classifying and distinguishing between models

H Innan, F Kondrashov - Nature Reviews Genetics, 2010 - nature.com
Gene duplications and their subsequent divergence play an important part in the evolution
of novel gene functions. Several models for the emergence, maintenance and evolution of …

Gene duplication as a mechanism of genomic adaptation to a changing environment

FA Kondrashov - Proceedings of the Royal Society B …, 2012 - royalsocietypublishing.org
… times more common in Antarctic cod suggesting that upregulation through gene duplication
of many different functions, including the well-characterized AFGP genes and FBP32II, an F-…

Role of selection in fixation of gene duplications

FA Kondrashov, AS Kondrashov - Journal of Theoretical Biology, 2006 - Elsevier
… 1E and F). If we assume that this result remains valid for gaps with very large l (on which we
had too few data points) and also reflects the properties of de novo mutations, and that long …

[HTML][HTML] The ctenophore genome and the evolutionary origins of neural systems

…, JP Rast, R Derelle, VV Solovyev, FA Kondrashov… - Nature, 2014 - nature.com
f, Relationships among major animal clades with choanoflagellates sister to all Metazoa. …
(refs 59) using maximum likelihood (ML) with the CAT +WAG + F model. Topological …

[HTML][HTML] Selection in the evolution of gene duplications

FA Kondrashov, IB Rogozin, YI Wolf, EV Koonin - Genome biology, 2002 - Springer
… The fitness of an organism with two gene copies is f(p) = 2p = 2(2) = 4, the fitness of the same
organism with two gene copies and one point mutation is f(p) = 2(2 - 1/10) = 3.8; in this case…

Interactions among quantitative traits in the course of sympatric speciation

AS Kondrashov, FA Kondrashov - Nature, 1999 - nature.com
Sympatric speciation, the origin of two or more species from a single local population, has
almost certainly been involved in formation of several species flocks 1 , 2 , 3 , 4 , and may be …

Local fitness landscape of the green fluorescent protein

…, ES Egorov, MD Logacheva, AS Kondrashov… - Nature, 2016 - nature.com
… We therefore modelled F as a sigmoid function of p, which explained 85% of the initial
sample variance (σ 2 = 0.17). A more complex sigmoid-shaped fitness function refined with a …

Selection for short introns in highly expressed genes

…, SL Mekhedov, DL Hartl, EV Koonin, FA Kondrashov - Nature …, 2002 - nature.com
Transcription is a slow and expensive process: in eukaryotes, approximately 20 nucleotides
can be transcribed per second 1, 2 at the expense of at least two ATP molecules per …

Epistasis as the primary factor in molecular evolution

…, C Kemena, PK Vlasov, C Notredame, FA Kondrashov - Nature, 2012 - nature.com
… In this paper, Fyodor Kondrashov and colleagues provide a quantitative estimate of the
fraction of amino-acid substitutions in evolution that have been influenced by epistasis — …

Dobzhansky–Muller incompatibilities in protein evolution

AS Kondrashov, S Sunyaev… - Proceedings of the …, 2002 - National Acad Sciences
… after being isolated, and F in these proteins is not significantly different from F in the whole
set… closely related species F < 10 −5 , in an apparent discrepancy with our estimate of F ≈ 10 −…