The histiocytoses are rare disorders characterized by the accumulation of macrophage,
dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults. …

The PI3K–AKT–mTOR pathway is one of the most frequently dysregulated pathways in cancer
and, consequently, more than 40 compounds that target key components of this signalling …

Aberrations in various cellular signaling pathways are instrumental in regulating cellular
metabolism, tumor development, growth, proliferation, metastasis and cytoskeletal …

Autophagy is an important homeostatic cellular recycling mechanism responsible for
degrading unnecessary or dysfunctional cellular organelles and proteins in all living cells. …

… Three patients had pretreatment and follow-up [ 18 F]fluorodeoxyglucose positron
emission tomography; two of these patients had a metabolic response with greater than 25% …

Purpose: The superiority of chemoradiotherapy (CRT) over radiation alone in locally
advanced non-small cell lung cancer (NSCLC) has been proven, but the relative merits of a …

… F. Janku has a commercial research grant from Novartis. D. Berry is a paid consultant and
co-owner of Berry Consultants, whose clients include some of the sponsors of clinical trials …

… (F) Sagittal postgadolinium T1 MRI shows thickening and enhancement of the pituitary stalk.
… (F) Sagittal postgadolinium T1 MRI shows thickening and enhancement of the pituitary stalk. …

… F. Janku reports receiving commercial research grants from Biocartis, Foundation Medicine,
and Trovagene and is a consultant/advisory board member for Trovagene. A. Dogan is a …

… Provision of study materials or patients: Filip Janku, Jennifer J. Wheler, Shannon N.
Westin, Stacy L. … Collection and assembly of data: Filip Janku, Ignacio Garrido-Laguna …