[HTML][HTML] Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
Background Type 1 diabetes mellitus is a T-cell–mediated autoimmune disease that leads
to a major loss of insulin-secreting beta cells. The further decline of beta-cell function after …
to a major loss of insulin-secreting beta cells. The further decline of beta-cell function after …
The CTLA-4 Gene Region of Chromosome 2q33 Is Linked to, and Associated with, Type 1 Diabetes
…, CL Vandewalle, F Schuit, FK Gorus… - Human molecular …, 1996 - academic.oup.com
Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus is determined by
a combination of environmental and genetic factors, which include variation in MHC genes …
a combination of environmental and genetic factors, which include variation in MHC genes …
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
…, L Mortelmans, B Gallez, F Gorus, J Buyse, F Sluse… - Nature …, 2008 - nature.com
HIF prolyl hydroxylases (PHD1–3) are oxygen sensors that regulate the stability of the
hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of …
hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of …
Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock
…, C Garbar, LP Huyghens, FK Gorus - Clinical …, 2000 - academic.oup.com
… Frans K Gorus Frans K Gorus … Alia I, Esteban A, Gordo F, Lorente JA, Diaz C, Rodriguez
JA, Frutos F. A randomized and controlled trial of the effect of treatment aimed at maximizing …
JA, Frutos F. A randomized and controlled trial of the effect of treatment aimed at maximizing …
Plasma procalcitonin and C-reactive protein in acute septic shock: clinical and biological correlates
…, H Spapen, K ver Elst, L Huyghens, FK Gorus - Advances in Critical …, 2004 - Springer
Elevated procalcitonin (PCT) levels are markers of sepsis but their prognostic value and
relation to other inFlammatory parameters and calcium homeostasis remains controversial. We …
relation to other inFlammatory parameters and calcium homeostasis remains controversial. We …
Restoring a functional β‐cell mass in diabetes
…, G Martens, B Keymeulen, F Gorus - Diabetes, Obesity …, 2008 - Wiley Online Library
Type 1 and type 2 diabetes have often been presented as disease forms that profoundly
differ in the presence and pathogenic significance of a reduced β‐cell mass. We review …
differ in the presence and pathogenic significance of a reduced β‐cell mass. We review …
[HTML][HTML] Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline …
Aims/hypothesis The aim of the study was to examine the 48 month outcome of treating
recent-onset type 1 diabetic patients for 6 days with humanised CD3-antibody, ChAglyCD3. …
recent-onset type 1 diabetic patients for 6 days with humanised CD3-antibody, ChAglyCD3. …
[HTML][HTML] Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient
…, L Schoonjans, G Delvaux, BL Strand, F Gorus… - Diabetologia, 2013 - Springer
Methods Cultured human islet cells were equally distributed over free and alginate-encapsulated
grafts before implantation in, respectively, the kidney capsule and the peritoneal cavity …
grafts before implantation in, respectively, the kidney capsule and the peritoneal cavity …
[HTML][HTML] Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation
…, K Verbeeck, BZ Alizadeh, C Mathieu, FK Gorus… - PloS one, 2008 - journals.plos.org
Background Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of
recipients remains insulin–independent in the following years. We tested the hypothesis that …
recipients remains insulin–independent in the following years. We tested the hypothesis that …
Beta-cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA-DQ types in type 1 diabetes
…, F Winnock, J Van Autreve, FK Gorus - Clinical & …, 2001 - academic.oup.com
The autoimmune attack in type 1 diabetes is not only targeted to β cells. We assessed the
prevalence of thyroid peroxidase (aTPO), parietal cell (PCA), antiadrenal (AAA) and …
prevalence of thyroid peroxidase (aTPO), parietal cell (PCA), antiadrenal (AAA) and …