The tumor microenvironment (TME) is a multifaceted ecosystem characterized by profound
cellular heterogeneity, dynamicity, and complex intercellular cross-talk. The striking …

Screening drugs on patient biopsies from solid tumours has immense potential, but is challenging
due to the small amount of available material. To address this, we present here a plug-…

Engineering and computational advances have opened many new avenues in cancer
research, particularly when being exploited in interdisciplinary approaches. For example, the …

The ability to computationally predict the effects of toxic compounds on humans could help
address the deficiencies of current chemical safety testing. Here, we report the results from a …

… Another relevant positive biomarker for all 18 cancer types is B2M / HLA-F. Although this
is an intracellular interaction rather than an LR pair, the importance of this interaction for the …

… of τ i represent faster response, interpretable as more functional species; x 1,i , x 2,i , …, x
N,i are the N regulators of x i and each regulation is defined by a sigmoidal transfer function f(x i…

… As previously described (Eduati et al, 2017), we consider one parameter for each edge j →
i in the network, which characterize the strength of the regulation of species i dependent on …

… Federica Eduati , Federica Eduati … It furthers the University's objective of excellence in
research, scholarship, and education by publishing worldwide …

… (f) The degree of T cell infiltration can affect ICBs effectiveness. (g) Signaling pathways are
responsible for the correct functioning of the cells. Cancer is caused by deregulations in these …

Objectives Pathologic subtyping of tissue biopsies is the gold standard for the diagnosis of
lung cancer (LC), which could be complicated in cases of eg inconclusive tissue biopsies or …