BACKGROUND: Candidate gene analysis has been frequently used in attempts to understand
the pathological processes involved in many aspects of AAA disease. METHODS: This …

Heart Failure (HF) is a common disorder associated with substantial morbidity and mortality.
β adrenergic receptors (βAR) are the primary pathway through which cardiac function is …

For DNA-based tests that assess genetic predisposition to coronary heart disease (CHD) to
be of clinical value, they need to provide information over and above conventional risk …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…

Height is a highly heritable, classic polygenic trait with approximately 700 common associated
variants identified through genome-wide association studies so far. Here, we report 83 …

Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian …

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

Background Familial hypercholesterolaemia is a common autosomal-dominant disorder
caused by mutations in three known genes. DNA-based cascade testing is recommended by …

Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI),
implicating pathways related to neuronal biology. Most GWAS loci represent clusters of …