Patients with cancer carry somatic sequence variants in their tumour in addition to the
germline variants in their inherited genome. Although variants in protein-coding regions have …

Anaerobic digestion (AD) could be considered as a mature technology and nowadays it can
still play a pivot role because of the urgent need to provide renewable energy sources and …

Recognizing greywater as a relevant secondary source of water and nutrients represents an
important chance for the sustainable management of water resource. In the last two decades…

A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…

Toward development of a precision medicine framework for metastatic, castration-resistant
prostate cancer (mCRPC), we established a multi-institutional clinical sequencing …

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Prostate cancer is the second most common cause of male cancer deaths in the United
States. However, the full range of prostate cancer genomic alterations is incompletely …

The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes,
but the spectrum of genome-wide alterations has not been profiled extensively in this …

Comprehensive knowledge of the genomic alterations that underlie cancer is a critical
foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to analyze …

Prostate cancer is the second most common cancer in men worldwide and causes over
250,000 deaths each year 1 . Overtreatment of indolent disease also results in significant …