10.7554/eLife.03401.001 Gene drives may be capable of addressing ecological problems by
altering entire populations of wild organisms, but their use has remained largely theoretical …

Human pathogens that are transmitted by insects are a global problem, particularly those
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species, and …

The success of the sterile insect technique (SIT) and other genetic strategies designed to
eliminate large populations of insects relies on the efficient inundative releases of competitive, …

INTRODUCTION Control of mosquito vectors has historically proven to be an effective
means of eliminating malaria. Human malaria is transmitted only by mosquitoes in the genus …

Anopheline mosquito species are obligatory vectors for human malaria, an infectious disease
that affects hundreds of millions of people living in tropical and subtropical countries. The …

… in the complex, as reproductive isolation is incomplete: Adult female F 1 hybrids—although
uncommon in nature—are fertile and vigorous (only F 1 hybrid males are sterile) (10). …

Genes in sexually reproducing organisms normally have, on average, a 50% chance of
being inherited, but some genes have a higher chance of being inherited. These genes can …

Malaria kills millions of people every year, and new control measures are urgently needed.
The recent demonstration that (effector) genes can be introduced into the mosquito germ line …

Genetic modification of mosquitoes offers exciting possibilities for controlling malaria, but
success will depend on how transformation affects the fitness of modified insects. The …

Antimalarial drugs have thus far been chiefly derived from two sources—natural products
and synthetic drug-like compounds. Here we investigate whether antimalarial agents with …