Validation metrics are key for tracking scientific progress and bridging the current chasm
between artificial intelligence research and its translation into practice. However, increasing …

Recent technical developments have enabled the transcriptomes of hundreds of cells to be
assayed in an unbiased manner, opening up the possibility that new subpopulations of cells …

The temporal order of differentiating cells is intrinsically encoded in their single-cell expression
profiles. We describe an efficient way to robustly estimate this order according to diffusion …

Diffusion maps are a spectral method for non-linear dimension reduction and have recently
been adapted for the visualization of single-cell expression data. Here we present destiny, …

… 7F). More information on Gaussian width determination and two-… (F) The hierarchy of cells
for mouse embryonic stem cells … (F) The hierarchy of cells for mouse embryonic stem cells …

Multi‐omics studies promise the improved characterization of biological processes across
molecular layers. However, methods for the unsupervised integration of the resulting …

Heterogeneity within the self-renewal durability of adult hematopoietic stem cells (HSCs)
challenges our understanding of the molecular framework underlying HSC function. Gene …

… where f j is a Boolean formula that has and-nodes of in-degree two and/or-nodes of arbitrary
in-degree, and where f 1 has a maximum depth of N i and f 2 has a maximum depth of M i . …

Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …

… repetitive induction of inflammation, competitive transplantation assays were performed
using BM harvested from mice exposed to one, two or three blocks of pI:pC treatment (Figure 1F)…