User profiles for F. Barthel

Floris P Barthel

The Translational Genomics Research Institute (TGen)
Verified email at tgen.org
Cited by 6822

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future …

…, BM Alexander, JS Barnholtz-Sloan, FP Barthel… - Neuro …, 2020 - academic.oup.com
Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

[PDF][PDF] Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma

M Ceccarelli, FP Barthel, TM Malta, TS Sabedot… - Cell, 2016 - cell.com
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …

[PDF][PDF] Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment

…, AC DeCarvalho, S Lyu, P Li, Y Li, F Barthel… - Cancer cell, 2017 - cell.com
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …

Comprehensive and integrated genomic characterization of adult soft tissue sarcomas

…, S Sadeghi, FP Barthel, R Verhaak, X Hu, F Chibon… - Cell, 2017 - discovery.ucl.ac.uk
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …

[PDF][PDF] Glioma progression is shaped by genetic evolution and microenvironment interactions

…, K Aldape, A Ismail, SK Sivajothi, FP Barthel… - Cell, 2022 - cell.com
The factors driving therapy resistance in diffuse glioma remain poorly understood. To
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …

[HTML][HTML] Reconstructing the molecular life history of gliomas

FP Barthel, P Wesseling, RGW Verhaak - Acta neuropathologica, 2018 - Springer
At the time of their clinical manifestation, the heterogeneous group of adult and pediatric
gliomas carries a wide range of diverse somatic genomic alterations, ranging from somatic …

Longitudinal molecular trajectories of diffuse glioma in adults

FP Barthel, KC Johnson, FS Varn, AD Moskalik… - Nature, 2019 - nature.com
The evolutionary processes that drive universal therapeutic resistance in adult patients with
diffuse glioma remain unclear 1 , 2 . Here we analysed temporally separated DNA-…

Systematic analysis of telomere length and somatic alterations in 31 cancer types

FP Barthel, W Wei, M Tang, E Martinez-Ledesma… - Nature …, 2017 - nature.com
Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across 31 …

Normalizing economic loss from natural disasters: A global analysis

E Neumayer, F Barthel - Global Environmental Change, 2011 - Elsevier
… 5(a–f) we therefore look at developed vis-à-vis developing countries as well as at specific
regions of the world, employing the same list of weather-related disasters as in Fig. 4. Looking …

Transport buyers choice of transport service–A literature review of empirical results

J Flodén, F Bärthel, E Sorkina - Research in Transportation Business & …, 2017 - Elsevier
Highlights • Price is most important when choosing transport services. • Quality related factors
are also of high importance. • Environmental impact is given very low importance. • There …