Comparative genomic hybridization studies have shown gains in chromosome region 2p as
the most common imbalance in classical Hodgkin lymphoma (cHL). The minimal region of …

Acute myeloid leukemias (AMLs) result from multiple genetic alterations in hematopoietic
stem cells. We describe a novel t(12;18)(p13;q12) involving ETV6 in a patient with AML. The …

Motivation: Gene fusions resulting from chromosomal aberrations are an important cause of
cancer. The complexity of genomic changes in certain cancer types has hampered the …

An important question in the field of cancer epigenetics involves the causes of CpG island
hypermethylation in tumor suppressor genes leading to transcriptional silencing. L. Di Croce …

Different mechanisms, such as chromosomal rearrangements, deletions, mutations, and
methylation/demethylation of the promoter regions of genes, have been shown to be involved in …

… Francisco J Novo … Novo FJ, Vizmanos JL: Chromosome translocations in cancer: computational
evidence for the random generation of double-strand breaks. Trends … Francisco J Novo …

It has been shown that methylation of CpG dinucleotides located in the promoter region of
TP53 is associated with low expression levels of this gene. We have analysed the methylation …

Many B‐cell malignancies bear chromosomal translocations juxtaposing immunoglobulin (IG)
genes with oncogenes, resulting in deregulated expression of the latter. Translocations …

Activation of an oncogene via its juxtaposition to the IGH locus by a chromosomal translocation
or, less frequently, by genomic amplification is considered a major mechanism of B‐cell …

Phenotypic and genotypic analyses of cells are increasingly essential for understanding
pathogenetic mechanisms as well as for diagnosing and classifying malignancies and other …