Minireview: epigenetics of obesity and diabetes in humans
H Slomko, HJ Heo, FH Einstein - Endocrinology, 2012 - academic.oup.com
Understanding the determinants of human health and disease is overwhelmingly complex,
particularly for common, late-onset, chronic disorders, such as obesity and diabetes. …
particularly for common, late-onset, chronic disorders, such as obesity and diabetes. …
[HTML][HTML] Humanin: a novel central regulator of peripheral insulin action
…, LJ Cobb, S Fishman, T Budagov, L Cui, FH Einstein… - PloS one, 2009 - journals.plos.org
Background Decline in insulin action is a metabolic feature of aging and is involved in the
development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and …
development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and …
Visceral adipose tissue modulates mammalian longevity
…, DM Huffman, X Ma, G Atzmon, FH Einstein… - Aging cell, 2008 - Wiley Online Library
Caloric restriction (CR) can delay many age‐related diseases and extend lifespan, while an
increase in adiposity is associated with enhanced disease risk and accelerated aging. …
increase in adiposity is associated with enhanced disease risk and accelerated aging. …
Differential responses of visceral and subcutaneous fat depots to nutrients
FH Einstein, G Atzmon, X Yang, XH Ma, M Rincon… - Diabetes, 2005 - Am Diabetes Assoc
Increased visceral adiposity is a pivotal component of the metabolic syndrome. Differential
gene expression patterns of fat-derived peptides (FDPs) in visceral fat and subcutaneous fat …
gene expression patterns of fat-derived peptides (FDPs) in visceral fat and subcutaneous fat …
Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats
…, H Chen, RH Muzumdar, FH Einstein… - American journal …, 2009 - journals.physiology.org
Assessing insulin resistance in rodent models gives insight into mechanisms that cause type
2 diabetes and the metabolic syndrome. The hyperinsulinemic euglycemic glucose clamp, …
2 diabetes and the metabolic syndrome. The hyperinsulinemic euglycemic glucose clamp, …
Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action
… approved by the animal care and use committee of the Albert Einstein College of Medicine.
… core laboratories of the Albert Einstein Diabetes Research and Training Center (DK 20541). …
… core laboratories of the Albert Einstein Diabetes Research and Training Center (DK 20541). …
Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo
…, G Atzmon, X Ma, X Yang, FH Einstein… - The FASEB …, 2007 - Wiley Online Library
Impairment of both insulin and leptin action has been implicated in the pathogenesis of
nonalcoholic fatty liver disease. By assessing hepatic triglyceride (TG) stores in response to …
nonalcoholic fatty liver disease. By assessing hepatic triglyceride (TG) stores in response to …
Epigenetic basis for fetal origins of age-related disease
RF Thompson, FH Einstein - Journal of Women's Health, 2010 - liebertpub.com
The current concept of fetal origins of adult diseases describes in utero programming, or
adaptation to a spectrum of adverse environmental conditions that ultimately leads to increased …
adaptation to a spectrum of adverse environmental conditions that ultimately leads to increased …
[HTML][HTML] Enhanced activation of a “nutrient-sensing” pathway with age contributes to insulin resistance
FH Einstein, S Fishman, J Bauman… - The FASEB …, 2008 - ncbi.nlm.nih.gov
Calorie restriction improves life span whereas nutrient excess leads to obesity and unfavorable
metabolic consequences, supporting the role for a cellular “nutrient sensor” in aging. …
metabolic consequences, supporting the role for a cellular “nutrient sensor” in aging. …
Aging per se increases the susceptibility to free fatty acid–induced insulin resistance
FH Einstein, DM Huffman, S Fishman… - … Series A: Biomedical …, 2010 - academic.oup.com
Elevations in systemic free fatty acids (FFA) contribute to insulin resistance. To determine
the effects of an acute elevation in FFA on insulin action with aging, we infused saline or …
the effects of an acute elevation in FFA on insulin action with aging, we infused saline or …