Changes in neuronal activity create local and transient changes in energy demands at
synapses. Here we discover a metabolic compartment that forms in vivo near synapses to meet …

Background The sugar sensing and carbon catabolite repression in Baker’s yeast Saccharomyces
cerevisiae is governed by three major signaling pathways that connect carbon source …

Production of chemicals in microbes often employs potent biosynthetic enzymes, which can
interact with the microbial native metabolism to affect cell fitness and product yield. However, …

Bile acids are essential molecules produced by vertebrates that are involved in several
physiological roles, including the uptake of nutrients. Bacterial isolates capable of producing bile …

Advances in DNA synthesis, sequencing and a deeper understanding of biological and
biochemical mechanisms have enabled the development of engineered microbes, and has …

Efficient bioconversion of the pentose xylose is vital for the development of competent
lignocellulose biorefineries. Although many proper attempts of metabolic engineering for …

The Giant Radio Array for Neutrino Detection (GRAND) is a planned large-scale observatory
of ultra-high-energy (UHE) cosmic particles, with energies exceeding 10 8 GeV. Its goal is …

Autonomous radio-detection, ie, detection of air-showers with standalone radio arrays, is
one of the major technical challenges to overcome for the next generation astroparticle …

The detection of extensive air showers (EAS) through their radio signal is becoming one of
the most promising techniques for the study of neutrinos and cosmic rays at the highest …

Simultaneous pancreas kidney transplantation (SPKT) is the treatment of choice for patients
with type 1 diabetes and end-stage renal disease. Rapamycin and mycophenolate mofetil (…