Recent data have paved the way to mechanistic studies into the role of Tbx1 during development.
Tbx1 is haploinsufficient and is involved in an important genetic disorder. The gene …

Rationale: TBX1 encodes a T-box transcription factor implicated in DiGeorge syndrome,
which affects the development of many organs, including the heart. Loss of Tbx1 results into …

Mutations of the Wnt5a gene, encoding a ligand of the non-canonical Wnt pathway, and the
Ror2 gene, encoding its receptor, have been found in patients with cardiac outflow tract …

Congenital heart disease (CHD) affects eight out of 1,000 live births and is a major social and
health-care burden. A common genetic cause of CHD is the 22q11.2 deletion, which is the …

Tbx1 is a T-box transcription factor implicated in DiGeorge syndrome. The molecular function
of Tbx1 is unclear although it can transactivate reporters with T-box binding elements. We …

The transcription factor TBX1 is the major gene involved in 22q11.2 deletion syndrome (22q11.2DS).
Using mouse models of these diseases, we have previously shown that TBX1 …

The TBX1 gene is haploinsufficient in 22q11.2 deletion syndrome (22q11.2DS), and genetic
evidence from human patients and mouse models points to a major role of this gene in the …

Cardiac progenitors (CPs) are specified during gastrulation among Mesp1-expressing cells [1].
Mesp1 is a transcription factor (TF) expressed transiently during gastrulation in cells that …

Cardiac progenitors (CPs) are specified during gastrulation among Mesp1-expressing cells [1].
Mesp1 is a transcription factor (TF) expressed transiently during gastrulation in cells that …

The TBX1 gene is haploinsufficient in the 22q11.2 deletion syndrome (22q11.2DS), and
genetic evidence from human patients and mouse models points to a major role of this gene in …