… This locus was also identified as a preferred proviral integration site in Cas-Br-E-induced
leukemias. A year after its discovery, Fli-1 was found to be a target of translocation in a majority …

Triple-negative breast cancer (TNBC) is a heterogeneous disease that includes Basal-like
and Claudin-low tumors. The Claudin-low tumors are enriched for features associated with …

A switch from catabolic to anabolic metabolism, a major hallmark of cancer, enables rapid
cell duplication, and is driven by multiple oncogenic alterations, including PIK3CA mutation, …

Background Retinoblastoma is the childhood retinal cancer that defined tumour-suppressor
genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma …

… Protein lysates (150 ~g) from brains and carcasses of RBlox/RB-/- and control fetuses were
immonoblotted and developed with polyclonal antibody to p107 (E) or p130 (F). The bottom …

PIK3CA, which codes for the p110α catalytic subunit of phosphatidylinositol 3-kinase, is one
of the most frequently mutated genes in human breast cancer. Here, we describe a mouse …

… Paraffin-embedded tissue samples were sectioned (4 μm) using a Reichert Ultracut E
microtome. Sections were deparaffinized by treating twice with xylene for 10 min each and …

Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for
which no specific treatment is currently available. Although the retinoblastoma tumor-suppressor …

Breast cancer is a highly heterogeneous disease, with several different subtypes being
characterized by distinct histology, gene expression patterns, and genetic alterations. The tumor …

Basal-like breast cancers (BLBC) express a luminal progenitor gene signature. Notch
receptor signaling promotes luminal cell fate specification in the mammary gland, while …