Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Background Crohn's disease and ulcerative colitis are the two major forms of inflammatory
bowel disease; treatment strategies have historically been determined by this binary …

Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect
millions of people worldwide. Genome-wide association studies have identified 200 …

… Interestingly, while IKKa or IKKb single deficiency had little effect on apoptosis induction (Figures
1E–1H), their combined depletion mimicked the phenotype observed in the Nemo …

GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of
disease associations are known to be driven by regulatory variants. To identify the putative …

Epilepsy comprises several syndromes, amongst the most common being mesial temporal
lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with …

… fragment lengths are provided in Table 1 of the Electronic supplementary material (ESM). …
e, f Nitrite production measured in the medium collected from cells used in the viability assay …

Background— A limitation of current antiplatelet therapies is their inability to separate
thrombotic events from bleeding occurrences. A better understanding of the molecular …

… theatre studies course, we were struck by the parallels between the role of the theatre …
the rapidly shifting and changing e‐learning environment. We noticed that, like an engaging …

Infliximab, a chimeric anti-tumour necrosis factor (TNF)-α antibody induces a clinical
response in 70% of Crohn's disease patients and the response to infliximab therapy could be …