4C-Seq has proven to be a powerful technique to identify genome-wide interactions with a
single locus of interest (or “bait”) that can be important for gene regulation. However, analysis …

Interrogation of disease-relevant cellular and molecular traits exhibited by genetically diverse
cell populations enables in vitro systems genetics approaches for uncovering the basic …

… e The left plot shows the number of annotated integrations in the mm10 genome for each
ERV (annotated), the number of predicted integrations and the number of observed bait-like …

During class switch recombination (CSR), B cells replace the Igh Cμ or δ exons with another
downstream constant region exon (C H ), altering the antibody isotype. CSR occurs through …

Loss of imprinting (LOI) results in severe developmental defects, but the mechanisms preventing
LOI remain incompletely understood. Here, we dissect the functional components of the …

Altered innate immunity is a feature of certain skin inflammatory diseases such as psoriasis
and atopic dermatitis (AD). In this study, we provide evidence that deficiency in Trim32 (a …

Psoriasis is a common inflammatory skin disease resulting from genetic and environmental
alterations of cutaneous immune responses. While numerous therapeutic targets involved in …

… Swanzey et al. provide strong evidence that this instability at imprinted loci is controlled by
genetic determinants and map a candidate regulator to a region on mouse chromosome 13. …

… (E) Possible applications of the Dlk1 reporter model to study … (E) Possible applications of
the Dlk1 reporter model to study … (E) Possible applications of the Dlk1 reporter model to study …

Outbred laboratory mice (Mus musculus) are readily available and have high fecundity,
making them a popular choice in biomedical research, especially toxicological and …