Understanding the tumor immune microenvironment (TIME) for effective therapy
M Binnewies, EW Roberts, K Kersten, V Chan… - Nature medicine, 2018 - nature.com
The clinical successes in immunotherapy have been both astounding and at the same time
unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical …
unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical …
Electrode passivation, faradaic efficiency, and performance enhancement strategies in electrocoagulation—a review
Treating water and wastewater is energy-intensive, and traditional methods that require
large amounts of chemicals are often still used. Electrocoagulation (EC), an electrochemical …
large amounts of chemicals are often still used. Electrocoagulation (EC), an electrochemical …
Stromal cells in the tumor microenvironment
The tumor microenvironment comprises a mass of heterogeneous cell types, including
immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly …
immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly …
[BOOK][B] Entrepreneurs in high technology: Lessons from MIT and beyond
EB Roberts - 1991 - books.google.com
The ingredients for success in starting and developing a technology-based company aren't
obvious. Why, for example, did Digital Equipment Corporation succeed--and indeed become …
obvious. Why, for example, did Digital Equipment Corporation succeed--and indeed become …
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer
…, DS Chan, CM Connell, EW Roberts… - Proceedings of the …, 2013 - National Acad Sciences
An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis
of why immunotherapy is ineffective in this human disease. Despite finding that PDA-…
of why immunotherapy is ineffective in this human disease. Despite finding that PDA-…
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein–α
M Kraman, PJ Bambrough, JN Arnold, EW Roberts… - Science, 2010 - science.org
The stromal microenvironment of tumors, which is a mixture of hematopoietic and mesenchymal
cells, suppresses immune control of tumor growth. A stromal cell type that was first …
cells, suppresses immune control of tumor growth. A stromal cell type that was first …
What we've learned: Managing invention and innovation
EB Roberts - Research-Technology Management, 1988 - Taylor & Francis
… consulting firm of PughRoberts Associates, Inc. since 1963, Roberts has developed its
dual … Immodestly I also suggest further reading of my recent work, Roberts and Fusfeld, “Staffing …
dual … Immodestly I also suggest further reading of my recent work, Roberts and Fusfeld, “Staffing …
[PDF][PDF] Entering new businesses: Selecting strategies for success
EB Roberts, CA Berry - 1984 - dspace.mit.edu
Selection from the alternative strategies available for entering new businesses is a key
issue for diversifying corporations. Alternative approaches include internal development, …
issue for diversifying corporations. Alternative approaches include internal development, …
[HTML][HTML] Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection
…, DM Fremgen, E Roberts, F Scott, E Martinborough… - Cell, 2011 - cell.com
Cytokine storm during viral infection is a prospective predictor of morbidity and mortality, yet
the cellular sources remain undefined. Here, using genetic and chemical tools to probe …
the cellular sources remain undefined. Here, using genetic and chemical tools to probe …
[PDF][PDF] Critical role for CD103+/CD141+ dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma
EW Roberts, ML Broz, M Binnewies, MB Headley… - Cancer cell, 2016 - cell.com
Intratumoral dendritic cells (DC) bearing CD103 in mice or CD141 in humans drive intratumoral
CD8 + T cell activation. Using multiple strategies, we identified a critical role for these …
CD8 + T cell activation. Using multiple strategies, we identified a critical role for these …