Pathogenic Mycobacterium reside inside vacuoles in their host macrophages. These vacuoles
fail to fuse with lysosomes yet interact with early endosomes. Glycoconjugates released …

In an extensive review in 1935, pneumonia was mentioned in 08 per cent of 2.534 cases of
varicella (10) and was believed to be the result of secondary infection with streptococ-cus in …

Background—Whether diabetes mellitus (DM) adversely affects left ventricular (LV) structure
and function independently of increases in body mass index (BMI) and blood pressure is …

Highlights • Intrinsically disordered proteins have diverse roles in macromolecular complexes.
• Short sequences, repeated within disordered regions give rise to multivalent binding …

Background—Although cardiovascular disease (CVD) used to be rare among American
Indians, Indian Health Service data suggest that CVD mortality rates vary greatly among …

ContextThe duration of protection from tuberculosis of BCG vaccines is not known.ObjectiveTo
determine the long-term duration of protection of a BCG vaccine that was previously …

Parkinson's disease is characterized by the presence of intracellular aggregates composed
primarily of the neuronal protein α-synuclein (αS). Interactions between αS and various …

Recent theoretical work suggests that protein folding involves an ensemble of pathways on a
rugged energy landscape. We provide direct evidence for heterogeneous folding pathways …

Analysis of infected macrophages revealed that lipid‐containing moieties of the mycobacterial
cell wall are actively trafficked out of the mycobacterial vacuole. To facilitate the analysis …

The early phase of acquired cellular immunity to Mycobacterium tuberculosis infection is
mediated by the emergence of protective CD4 T lymphocytes that secrete cytokines including …