Precision psychiatry is an emerging field with transformative opportunities for mental health.
However, the use of clinical prediction models carries unprecedented ethical challenges, …

Atherosclerosis (AS), a major pathologic consequence of obesity, is the main etiological factor
of cardiovascular disease (CVD), which is the most common cause of death in the western …

Introduction: Individuals suffering from psychiatric disorders experience high levels of illness
burden and a significantly reduced quality of life. Despite targeted psychopharmacological …

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However, …

Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified …

Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD)
is complicated by variable length of treatment, unpredictable clinical course, and often …

Objectives There is evidence that the gut microbiota plays a major role in the pathogenesis
of diseases of the central nervous system through the gut–brain axis. The aim of the present …

Objective Obesity‐related immune mediated systemic inflammation was associated with the
development of the metabolic syndrome by induction of the tryptophan (TRP)–kynurenine (…

Gut microbiota are suspected to affect brain functions and behavior as well as lowering
inflammation status. Therefore, an effect on depression has already been suggested by recent …

Importance Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder
(BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%…