User profiles for E. Ramsay

EC Ramsay

- Verified email at precision-nano.com - Cited by 1977

Emma Ramsay

- Verified email at sydney.edu.au - Cited by 981

[HTML][HTML] Pharmacokinetic aspects of retinal drug delivery

…, AK Rimpelä, E Heikkinen, OK Kari, E Ramsay… - Progress in retinal and …, 2017 - Elsevier
Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or blindness. …

[HTML][HTML] The immune system in cancer metastasis: friend or foe?

LME Janssen, EE Ramsay, CD Logsdon… - … for immunotherapy of …, 2017 - Springer
Metastatic disease is the leading cause of death among cancer patients and involves a
complex and inefficient process. Every step of the metastatic process can be rate limiting and is …

Current status and future perspectives on MRNA drug manufacturing

…, A Thomas, S Clarke, EC Ramsay… - Molecular …, 2022 - ACS Publications
… The recombinant production of proteins in a host cell (E. coli) is a well-established platform.
Recombinant RNA production follows a similar principle: the DNA encoding mRNA of …

[PDF][PDF] Comparison of breast magnetic resonance imaging, mammography, and ultrasound for surveillance of women at high risk for hereditary breast cancer

…, LS Di Prospero, MJ Yaffe, V Goel, E Ramsay… - Journal of Clinical …, 2001 - pkdiet.com
Purpose: Recommended surveillance for BRCA1 and BRCA2 mutation carriers includes
regular mammography and clinical breast examination, although the effectiveness of these …

Germline mutations in RAD51D confer susceptibility to ovarian cancer

…, C Turnbull, E Ramsay, D Hughes, E Ruark… - Nature …, 2011 - nature.com
Recently, RAD51C mutations were identified in families with breast and ovarian cancer 1 .
This observation prompted us to investigate the role of RAD51D in cancer susceptibility. We …

Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability

…, S Seal, E Ruark, J Harmer, E Ramsay… - Nature …, 2014 - nature.com
Overgrowth disorders are a heterogeneous group of conditions characterized by increased
growth parameters and other variable clinical features such as intellectual disability and …

Ratiometric dosing of anticancer drug combinations: controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice

…, CR Shew, SA Johnstone, EC Ramsay… - Molecular cancer …, 2006 - AACR
… times more active than a saline-based combination in which each drug was escalated to its
MTD (log cell kill value of 0.57 for 148:1,000 μmol/kg irinotecan/floxuridine; Table 1, column E

Germline RAD51C mutations confer susceptibility to ovarian cancer

…, C Turnbull, E Ruark, RMM Xicola, E Ramsay… - Nature …, 2012 - nature.com
In 2010, Meindl and colleagues proposed that germline RAD51C mutations confer high risk
for breast and ovarian cancer, comparable to BRCA1 and BRCA2 mutations1, 2. However, …

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

…, DN Rodrigues, A Renwick, S Seal, E Ramsay… - Nature, 2013 - nature.com
Improved sequencing technologies offer unprecedented opportunities for investigating the
role of rare genetic variation in common disease. However, there are considerable …

[HTML][HTML] Long-term results of screening with magnetic resonance imaging in women with BRCA mutations

…, RA Jong, FC Wright, MJ Yaffe, EA Ramsay… - British journal of …, 2012 - nature.com
Background: The addition of breast magnetic resonance imaging (MRI) to screening
mammography for women with BRCA mutations significantly increases sensitivity, but there is little …