[HTML][HTML] Pharmacokinetic aspects of retinal drug delivery
…, AK Rimpelä, E Heikkinen, OK Kari, E Ramsay… - Progress in retinal and …, 2017 - Elsevier
Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or blindness. …
because many diseases affect the retina and choroid leading to impaired vision or blindness. …
[HTML][HTML] The immune system in cancer metastasis: friend or foe?
LME Janssen, EE Ramsay, CD Logsdon… - … for immunotherapy of …, 2017 - Springer
Metastatic disease is the leading cause of death among cancer patients and involves a
complex and inefficient process. Every step of the metastatic process can be rate limiting and is …
complex and inefficient process. Every step of the metastatic process can be rate limiting and is …
Current status and future perspectives on MRNA drug manufacturing
…, A Thomas, S Clarke, EC Ramsay… - Molecular …, 2022 - ACS Publications
… The recombinant production of proteins in a host cell (E. coli) is a well-established platform.
Recombinant RNA production follows a similar principle: the DNA encoding mRNA of …
Recombinant RNA production follows a similar principle: the DNA encoding mRNA of …
[PDF][PDF] Comparison of breast magnetic resonance imaging, mammography, and ultrasound for surveillance of women at high risk for hereditary breast cancer
…, LS Di Prospero, MJ Yaffe, V Goel, E Ramsay… - Journal of Clinical …, 2001 - pkdiet.com
Purpose: Recommended surveillance for BRCA1 and BRCA2 mutation carriers includes
regular mammography and clinical breast examination, although the effectiveness of these …
regular mammography and clinical breast examination, although the effectiveness of these …
Germline mutations in RAD51D confer susceptibility to ovarian cancer
…, C Turnbull, E Ramsay, D Hughes, E Ruark… - Nature …, 2011 - nature.com
Recently, RAD51C mutations were identified in families with breast and ovarian cancer 1 .
This observation prompted us to investigate the role of RAD51D in cancer susceptibility. We …
This observation prompted us to investigate the role of RAD51D in cancer susceptibility. We …
Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability
…, S Seal, E Ruark, J Harmer, E Ramsay… - Nature …, 2014 - nature.com
Overgrowth disorders are a heterogeneous group of conditions characterized by increased
growth parameters and other variable clinical features such as intellectual disability and …
growth parameters and other variable clinical features such as intellectual disability and …
Ratiometric dosing of anticancer drug combinations: controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice
…, CR Shew, SA Johnstone, EC Ramsay… - Molecular cancer …, 2006 - AACR
… times more active than a saline-based combination in which each drug was escalated to its
MTD (log cell kill value of 0.57 for 148:1,000 μmol/kg irinotecan/floxuridine; Table 1, column E…
MTD (log cell kill value of 0.57 for 148:1,000 μmol/kg irinotecan/floxuridine; Table 1, column E…
Germline RAD51C mutations confer susceptibility to ovarian cancer
In 2010, Meindl and colleagues proposed that germline RAD51C mutations confer high risk
for breast and ovarian cancer, comparable to BRCA1 and BRCA2 mutations1, 2. However, …
for breast and ovarian cancer, comparable to BRCA1 and BRCA2 mutations1, 2. However, …
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer
…, DN Rodrigues, A Renwick, S Seal, E Ramsay… - Nature, 2013 - nature.com
Improved sequencing technologies offer unprecedented opportunities for investigating the
role of rare genetic variation in common disease. However, there are considerable …
role of rare genetic variation in common disease. However, there are considerable …
[HTML][HTML] Long-term results of screening with magnetic resonance imaging in women with BRCA mutations
Background: The addition of breast magnetic resonance imaging (MRI) to screening
mammography for women with BRCA mutations significantly increases sensitivity, but there is little …
mammography for women with BRCA mutations significantly increases sensitivity, but there is little …