The group A Streptococcus small regulatory RNA FasX enhances streptokinase activity by increasing the stability of the ska mRNA transcript

E RamirezPeņa, J Treviņo, Z Liu… - Molecular …, 2010 - Wiley Online Library
Small RNA molecules play key regulatory roles in many bacterial species. However, little
mechanistic data exists for the action of small regulatory RNAs in the human pathogen group A …

CovS Simultaneously Activates and Inhibits the CovR-Mediated Repression of Distinct Subsets of Group A Streptococcus Virulence Factor-Encoding Genes

J Trevino, N Perez, E Ramirez-Pena, Z Liu… - Infection and …, 2009 - Am Soc Microbiol
To colonize and cause disease at distinct anatomical sites, bacterial pathogens must tailor
gene expression in a microenvironment-specific manner. The molecular mechanisms that …

[HTML][HTML] GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

…, M Pietila, JH Taube, TR Sarkar, E Ramirez-Pena… - Breast Cancer …, 2019 - Springer
… and a decrease in the expression of epithelial markers such as E-cadherin [9, 10]. Several
… At the transcript level, we found that the E-cadherin expression was increased by treatment …

GD3 synthase regulates epithelial–mesenchymal transition and metastasis in breast cancer

…, VL Battula, SJ Werden, GV Vijay, EQ Ramirez-Peņa… - Oncogene, 2015 - nature.com
The epithelial–mesenchymal transition (EMT) bestows cancer cells with increased stem cell
properties and metastatic potential. To date, multiple extracellular stimuli and transcription …

[HTML][HTML] Distinguishing mechanisms underlying EMT tristability

…, M Lu, M Celiktas, E Ramirez-Peņa, E Ben-Jacob… - Cancer …, 2017 - Springer
… Next, to investigate the gene expression levels of ZEB1 across E, hybrid E/M and M cells,
we analyze the NCI-60 panel of cell lines that have been classified into E, E/M, and M …

[HTML][HTML] Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth

…, AM LaBaff, JH Taube, BG Hollier, EQ Ramirez-Peņa… - Oncogene, 2016 - nature.com
Metastatic competence is contingent upon the aberrant activation of a latent embryonic
program, known as the epithelial–mesenchymal transition (EMT), which bestows stem cell …

[HTML][HTML] EMT-induced metabolite signature identifies poor clinical outcome

SK Bhowmik, E Ramirez-Peņa, JM Arnold, V Putluri… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Metabolic reprogramming is a hallmark of cancer. Epithelial-mesenchymal transition (EMT)
induces cancer stem cell (CSC) characteristics and promotes tumor invasiveness; however …

UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression

…, F Gu, CR Ambati, U Rasaily, E Ramirez-Pena… - Oncogene, 2020 - nature.com
An improved understanding of the biochemical alterations that accompany tumor progression
and metastasis is necessary to inform the next generation of diagnostic tools and targeted …

The small regulatory RNA FasX controls pilus expression and adherence in the human bacterial pathogen group A Streptococcus

Z Liu, J Treviņo, E RamirezPeņa… - Molecular …, 2012 - Wiley Online Library
Bacterial pathogens use cell surface‐associated adhesion molecules to promote host
attachment and colonization, and the ability to modulate adhesion expression is critical to …

[HTML][HTML] The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression

E Ramirez-Peņa, J Arnold, V Shivakumar, R Joseph… - Cancers, 2019 - mdpi.com
Identifying bioenergetics that facilitate the epithelial to mesenchymal transition (EMT) in breast
cancer cells may uncover targets to treat incurable metastatic disease. Metastasis is the …