The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients currently …

Over the last decade, invasive fungal infections have emerged as a growing threat to
human health worldwide and novel treatment strategies are urgently needed. In this context, …

The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid
cells sensing diverse entities including pathogens and damaged cells. Mincle was first …

… Here, λ = p O,i /p E , where p O,i is the observed proportion of SNPs of a given class in the
i th bin of the distribution and p E is the expected proportion of SNPs of a given class in that …

Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the
extent of population differences in immune responses and their genetic and evolutionary …

… selection is θ r /2 = 2N e μL r f 0 , where L r is the number of nucleotide sites at which a
mutation would generate an amino acid change, N e the effective population size and μ the …

… We thank E. Soumonni, a historian whose advice guided the recruitment of Beninese … We
thank E. Soumonni, a historian whose advice guided the recruitment of Beninese individuals, …

Human genes governing innate immunity provide a valuable tool for the study of the selective
pressure imposed by microorganisms on host genomes. A comprehensive, genome-wide …

The protein-coding exome of a patient with a monogenic disease contains about 20,000
variants, only one or two of which are disease causing. We found that 58% of rare variants in the …

The Pacific region is of major importance for addressing questions regarding human
dispersals, interactions with archaic hominins and natural selection processes 1 . However, the …