All cells must traffic proteins across their membranes. This essential process is responsible
for the biogenesis of membranes and cell walls, motility and nutrient scavenging and uptake, …

Recent work supports the idea that cisternae of the Golgi apparatus can be assigned to
three classes, which correspond to discrete stages of cisternal maturation. Each stage has a …

The Golgi apparatus is known to modify and sort newly synthesized secretory proteins.
However, fundamental mysteries remain about the structure, operation, and dynamics of this …

… Papanikou, Day et al. addressed this question using a technique called the “anchor-away
method” combined with microscopy to study COPI in yeast cells. The yeast were genetically …

… E. Papanikou carried out extensive exploratory studies that laid the foundation for this project.
JJ Barrero refined the tools for generating the regulatable fluorescent secretory cargo. BS …

SecA, the preprotein translocase ATPase, has a helicase DEAD motor. To catalyze protein
translocation, SecA possesses two additional flexible domains absent from other helicases. …

During the budding of coat protein complex II (COPII) vesicles from transitional endoplasmic
reticulum (tER) sites, Sec16 has been proposed to play two distinct roles: negatively …

The cornerstone of the functionality of almost all motor proteins is the regulation of their
activity by binding interactions with their respective substrates. In most cases, the underlying …

Objective. The goal of this study was to report the delivery outcomes in women who had
loop electrosurgical excision procedure (LEEP) for microinvasive cervical cancer (stage IA1 …

… To explore this discrepancy, we re-evaluated the rationale for using m×p E as an estimate
of E. Because the spatial and temporal resolution of the 4D movies was insufficient for …