The crystal structure of a complex containing the engrailed homeodom $ n and a duplex
DNA site has been determlned at 2.8 A resolution and refined to a crystallographic R factor of …

engrailed is a homeobox gene that has an important role in Drosophila segmentation.
Genes homologous to engrailed have been identified in several other organisms. Here we …

The activation of MAPKs is controlled by the balance between MAPK kinase and MAPK
phosphatase activities. The latter is mediated by a subset of phosphatases with dual specificity (…

We have examined wound healing during regeneration of Drosophila wing imaginal discs
fragments by confocal microscopy and assessed the role of components of the JNK pathway …

p38 MAPKs are a conserved subfamily of MAPKs involved in the response to stress found in
eukaryotic cells from yeast to mammals. The recent isolation of genes coding for members …

… (E) The basal lamina is absent between PS and larval cells (ultrathin electron microscope
… (E) Transmission electron micrograph of the leading front of a spreading imaginal wing disc (…

One of the fundamental events in metamorphosis in insects is the replacement of larval tissues
by imaginal tissues. Shortly after pupariation the imaginal discs evaginate to assume their …

… pathway and the signalling pathway activated by Dpp(Martin-Blanco et al., 1998; Riesgo-…
of larval cells during metamorphosis (reviewed by Martin-Blanco and Knust,2001). The …

Collective cell movement is a mechanism for invasion identified in many developmental
events. Examples include the movement of lateral-line neurons in Zebrafish, cells in the inner …

Cellular signaling networks have evolved to enable swift and accurate responses, even in
the face of genetic or environmental perturbation. Thus, genetic screens may not identify all …