Malignant brain tumors strike deep into the psyche of those receiving and those delivering
the diagnosis. Malignant gliomas, the most common subtype of primary brain tumors, are …

Families with autosomal dominant inherited predisposition to gastric cancer have been
described. More recently, germlineE-cadherin/CDH1mutations have been identified in hereditary …

… kinase inhibitors such as sorafenib and sunitinib inhibit the VEGF and PDGF receptors and
so block some of the effects of VHL inactivation (modified from Woodward and Maher 50 ). …

A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…

Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including
the regulation of genes involved in energy metabolism, angiogenesis and apoptosis 1 , 2 , 3 …

A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL)
disease tumor suppressor gene. A restriction fragment encompassing the gene showed …

This Letter reports results from the MINOS experiment based on its initial exposure to
neutrinos from the Fermilab NuMI beam. The rates and energy spectra of charged current ν μ …

Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans, but currently
do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known …

… By use of HotStar Taq (Qiagen), 50–100 ng of genomic DNA was amplified in Omn-E thermal
cyclers (Hybaid). Amplification conditions were as follows: initial denaturation at 95C for 10 …

… Data are reported on the basis of the electronic case‑report forms, rather than from information
in … in the trial and their families and caregivers; Adriana E. Tron, Ph.D., and Sung Choe, Ph.…